Dr. Joyce is Chief of the Structural Biology group within the Emerging Infectious Diseases Branch. His group utilizes structural biology with a focus on structure-based vaccine design, small molecule inhibitor design, and viral antigen-antibody structures. The structural biology group utilizes X-ray crystallography and electron microscopy to study and understand immune responses and vaccine-host-virus interactions, leveraging this information to develop medical countermeasures. Most recently, the group has focused on the design and development of a protective pan-sarbecovirus vaccine, and understanding the development of broadly protective immune responses following infection or vaccination.
Dr. Joyce received a B.Sc. (Hons) in Biochemistry from the National University of Ireland, Galway in 2001, followed by a Ph.D. in Structural Biology from the University of Leicester in 2006. He then began work on the structural characterization of human immunoreceptors with Dr. Peter Sun in the Laboratory of Immunogenetics at NIH. In 2011, he moved to the NIH’s Vaccine Research Center working with Dr. Gary Nabel, Dr. Peter Kwong and Dr. John Mascola on the structure-based design of HIV-1, Influenza and RSV vaccine candidates. In 2016, Dr. Joyce joined the Henry M. Jackson Foundation and established the structural biology group at WRAIR.
Dr. Joyce is an author of over 100 peer-reviewed scientific manuscripts focused on vaccine immunogens and monoclonal antibody therapeutics for coronaviruses, flaviviruses, herpesviruses, HIV-1, Influenza, RSV, and hMPV. He is a co-inventor on 20 awarded patents and over 50 patent pending applications, including technology used in the FDA-approved vaccines for COVID-19, and respiratory syncytial virus.